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24x7Report > Blog > Sports > College football odds, picks, predictions for Week 2, 2025: Model backing Mississippi State, Syracuse in bets
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College football odds, picks, predictions for Week 2, 2025: Model backing Mississippi State, Syracuse in bets

Last updated: 2025/09/05 at 4:39 PM
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High faculty soccer predictions for Week 2Tips on how to make faculty soccer picks for Week 2Week 2 faculty soccer odds for notable video games

The Week 2 faculty soccer schedule could lack the top-10 matchups that final Saturday noticed, however it is going to see two of the winningest applications within the historical past of the game colliding. No. 15 Michigan will head to Norman, Okla., to face the 18th-ranked Sooners, with OU 5.5-point favorites, after initially opening as 1.5-point favorites. The 2 colleges rank within the prime 5, all-time, in faculty soccer championships amongst main applications whereas every can be within the prime six in wins. Elsewhere, there are a number of matchups which function in-state battles as bragging rights will probably be on the road.

Iowa vs. Iowa State has been contested since 1894, and the most recent installment of the Cy-Hawk sequence sees the No. 16 Cyclones as 3.5-point favorites, in accordance with the Week 2 faculty soccer odds. There’s additionally Colorado vs. Delaware (+23.5) as Deion Sanders and firm will look to bounce again after a gap week loss. The identical goes for Invoice Belichick and UNC, because the Tar Heels are favored by 13.5 factors over Charlotte, per the Week 2 faculty soccer spreads. Earlier than locking in any Week 2 faculty soccer picks, you’ll want to see the latest Week 2 college football predictions from SportsLine’s proven model.

The mannequin simulates each FBS recreation 10,000 occasions. Since its inception, it has generated a betting revenue of effectively over $2,000 for $100 gamers on its top-rated faculty soccer unfold picks, and was a worthwhile 27-16 mixed on money-line and over/underneath college football picks in 2024. Anyone following its faculty soccer betting picks at sportsbooks and on betting websites may have seen sturdy returns.

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Now, it has turned its consideration to the most recent college football odds and Week 2 faculty soccer betting strains on the unfold, cash line, and over/underneath. Head here to see every pick, and new customers also can goal the DraftKings promo code, which provides new customers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

High faculty soccer predictions for Week 2

One of many faculty soccer picks the mannequin is excessive on throughout Week 2: Mississippi State (+6.5) covers at residence versus No. 12 Arizona State at 7:30 p.m. ET on Saturday. The Solar Devils are 0-2 all-time on the highway versus SEC opponents and 1-6 general in opposition to the convention. Whereas each groups are coming off double-digit victories in Week 1, solely Mississippi State coated, and it did it versus a superior opponent in Southern Miss. In the meantime, Arizona State performed an FCS faculty in Northern Arizona and wasn’t inside 10 factors of overlaying the 29.5-point unfold.

ASU defeated Mississippi State by only a landing when these two performed in Tempe, Ariz., final season because the Solar Devils wanted a 297-yard recreation from Cam Skattebo to get the win. Nonetheless, he is now within the NFL, and the Bulldogs’ run protection is vastly improved because it held Southern Miss to underneath 3.0 yards per carry. The Solar Devils are coming off a 12-penalty recreation of their opener and must deal with a Bulldogs program which clearly will get up for giant video games as MSU has coated in 4 straight versus ranked groups. The mannequin initiatives Mississippi State to cowl greater than 50% of the time. See which other picks the model likes here.

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One other prediction: Syracuse (-6.5) covers versus UConn on Saturday at midday ET. These former Massive East rivals have had a one-sided rivalry as of late, with the Orange successful every of the final 5 conferences. They’ve performed 4 occasions since 2016, with Syracuse successful all 4 by no less than 7 factors and having a median margin of victory of 19.5 factors. In final yr’s matchup, Cuse diced up Connecticut via the air with season highs in passing yards (470) and completion share (78.7) whereas having zero giveaways.

UConn quarterback Joe Fagnano is in his seventh yr of faculty soccer and his third at Connecticut, however he is but to win a highway recreation versus a Energy 4 workforce. In the meantime, Cuse QB Steve Angeli, who transferred from Notre Dame, has 5 touchdowns versus zero interceptions at residence in his collegiate profession. Search for him to benefit from a Huskies protection which is not the similar on the highway, as UConn gave up 311.4 passing yards in away video games in 2024, in comparison with 161.1 in residence video games. The Orange are forecasted to cowl nearly 60% of the time, with the Over (58.5) hitting in over 50% of simulations. See the rest of the model’s picks here.

Tips on how to make faculty soccer picks for Week 2

The mannequin has additionally made the decision on who wins and covers in each FBS matchup in Week 2, and it is calling for a ranked workforce to be upset in one of many week’s largest video games. You can only get every pick for every game at SportsLine, and for a restricted time you should use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.

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So what faculty soccer picks are you able to make with confidence, and which underdog wins outright? Try the most recent faculty soccer odds under, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and discover out.

Week 2 faculty soccer odds for notable video games

See full Week 2 college football picks, odds, predictions here

(odds topic to vary)

Friday, Sept. 5

James Madison vs. Louisville (-13.5, 56.5)

Maryland vs. Northern Illinois (+17.5, 46.5)

Saturday, Sept. 6

Illinois vs. Duke (+3, 49.5)

Iowa vs. Iowa State (-3, 41.5)

Virginia vs. NC State (-3, 54)

Texas vs. San Jose State (-36.5, 52.5)

Clemson vs. Troy (-33.5, 51.5)

Oregon State vs. Fresno State (+2.5)

Ole Miss vs. Kentucky (+10., 50.5)

Oregon vs. Oklahoma State (+28.5, 57.5)

Florida vs. South Florida (+17.5, 56)

Kansas State vs. Military (+17, 46.5)

LSU vs. Louisiana Tech (+37.5, 51.5)

Arizona State vs. Mississippi State (+6.5, 59)

Michigan vs. Oklahoma (-5.5, 46)

USC vs. Georgia Southern (+28.5, 60.5)

Alabama vs. UL Monroe (+36.5, 50.5)

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TAGGED: backing, Bets, College, football, Mississippi, Model, odds, Picks, Predictions, State, Syracuse, week

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