The NFL seems to be back-loading its schedule with divisional video games as, for the second week in a row, there are simply two divisional matchups you may goal in NFL betting and Week 6 NFL picks. Just one is on Sunday, with the Steelers vs. Browns (+5.5), and each groups performed the Vikings in Europe of their final video games, although in numerous weeks. Different Week 6 NFL spreads of no less than 5 factors embrace Rams vs. Ravens (+7.5), with Lamar Jackson’s availability doubtful, Jets vs. Broncos (-7.5) in London, Colts vs. Cardinals (+6.5) and Packers vs. Bengals (+14), wherein Joe Flacco will make his Cincy debut underneath middle.
The final of these matchups is the seventh sport this yr with an NFL line of greater than 9 factors, and heavy favorites are 3-3 ATS in these matchups. Thus, that NFL betting development will not assist a lot together with your Week 6 NFL predictions, however there are others that might definitely help with soccer bets. All the up to date Week 6 NFL strains are listed under, and SportsLine’s superior laptop mannequin has all of the NFL betting recommendation and NFL predictions you have to make the best Week 6 NFL picks now.
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The mannequin, which simulates each NFL sport 10,000 occasions, is up effectively over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin is on a scorching 41-21 run on top-rated picks courting again to 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites might have seen sturdy returns.
Now, it has turned its consideration to the most recent Week 6 NFL odds and NFL betting strains and locked in betting picks for each NFL matchup. Head here to see every pick.
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High Week 6 NFL predictions
We are able to inform you one of many mannequin’s strongest Week 6 NFL picks is that the Cowboys (-3, 49.5) cowl the unfold versus the Panthers in a Sunday 1 p.m. ET kickoff. Dallas has overcome CeeDee Lamb’s absence with 77 factors over its final two video games, each of which it lined. Dak Prescott has eight whole touchdowns, versus zero turnovers, over this span and his completion proportion over 2025 is the very best of his profession. He is being assisted by a dominant run sport that ranks within the high 10 in each yards per sport and yards per carry after rating twenty seventh or worse in each in 2024.
Dallas ought to feast off a Carolina protection which has the fewest sacks (5) within the NFL and the bottom strain charge. Carolina is not a lot better on offense, rating twenty fourth in scoring and twenty sixth in passing yards. The Panthers did win final week, however Bryce Younger has adopted up every of his final 4 victories with straight-up defeats. The mannequin has Dallas prevailing versus the unfold nearly 60% of the time in an A-rated decide. See which other teams to pick here.
Another one of its Week 6 NFL predictions: the Buccaneers (-3, 47.5) cover versus San Francisco in over 50% of simulations. Between their juggling of quarterbacks, just six teams have a worse turnover differential than the 49ers, who are also getting next to nothing in their run game. The team is dead last in yards per carry, and a one-dimensional offense may struggle to keep up with the Bucs. Baker Mayfield owns a 10:1 TD:INT, and Tampa ranks in the top 10 in both scoring offense and total offense.
San Fran does have a few extra days of rest after playing last Thursday, but that hasn’t necessarily been an omen to spread success. The team is just 2-4 ATS with a rest advantage over its last six games, and one can’t ignore the cross-country flight that the Niners will have to make. San Francisco played three games on the East Coast last season and failed to cover in all three. The model also says the Over hits well over 50% of the time. See which other teams to pick here.
How to make Week 6 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 6 NFL schedule and just revealed five teams that win by double-digits, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what Week 6 NFL picks can you make with confidence, and which five teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
