The Week 5 NFL schedule is the primary with byes, which means there are fewer contests to make Week 5 NFL bets on than earlier than. That additionally means you may dedicate extra time, power and assets to those matchups, which embody numerous inter-conference affairs. Jets vs. Cowboys (-2.5), Broncos vs. Eagles (-3.5), Bengals vs. Lions (-10.5) and Chargers vs. Commanders (+2.5) are among the AFC vs. NFC video games to put Week 5 NFL predictions on.
There is only one divisional recreation on Sunday and it sees the Payments internet hosting the Patriots (+8.5) on Sunday Evening Soccer. Some might desire making Week 5 NFL picks on frequent matchups like this one, or the rarer non-conference contests may drum up extra curiosity with NFL betting. The entire up to date Week 5 NFL traces are listed beneath, and SportsLine’s superior pc mannequin has all of the NFL betting recommendation and NFL predictions you should make the best Week 5 NFL picks now.
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The mannequin, which simulates each NFL recreation 10,000 occasions, is up effectively over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin is on a scorching 39-20 run on top-rated picks courting again to 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites may have seen sturdy returns.
Now, it has turned its consideration to the most recent Week 5 NFL odds and NFL betting traces and locked in betting picks for each NFL matchup. Head here to see every pick.
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High Week 5 NFL predictions
We are able to inform you one of many mannequin’s strongest Week 5 NFL picks is that the Saints (-1.5, 42) cowl the unfold versus the Giants in a Sunday 1 p.m. ET kickoff. Jaxson Dart picked up a win in his first begin, however the Giants additionally misplaced their finest offensive participant in dropping Malik Nabers for the season. New York had simply 89 crew passing yards on Sunday, whereas the crew averaged 243.3 passing yards with Russell Wilson beneath middle. Even with the increase that Dart offered, New York nonetheless struggles immensely on the opposite facet of the ball, rating thirtieth in each whole protection and run protection.
It is that run protection which might be a problem within the Superdome because the Saints have a top-10 dashing offense. The Saints are coming off masking versus the Payments during which three completely different gamers had at the least 49 dashing yards, and New Orleans had 189 yards on the bottom as a crew. The Saints have additionally racked up three-plus sacks in three of 4 video games this yr, whereas Dart was taken down 5 occasions in his beginning debut. The mannequin tasks New Orleans to have 4 QB takedowns because it stifles New York’s offense, permitting the Saints to cowl at dwelling effectively over 50% of the time. See which other teams to pick here.
Another one of its Week 5 NFL predictions: Cardinals (-7.5 42) cover versus Tennessee in well over 50% of simulations. Arizona will have some extra rest after playing last Thursday, and no one has performed better versus the spread against non-conference opponents. The Cardinals have covered in seven straight games versus the AFC, while Tennessee is 0-6 ATS versus the NFC since the start of last season. The Titans have dropped three straight overall versus the spread, meaning they’ve picked up where they left off last year as their 3-18 spread record since 2024 is the worst in the NFL.
Tennessee was shut out, 26-0, by the previously winless Texans on Sunday, as the Titans have lost 10 straight games overall. They rank last in both points scored and yards gained, while sitting 26th in points allowed and yards allowed. Arizona has the No. 5 scoring defense and the No. 8 run defense, which could make the Titans overly rely on top pick Cam Ward. However, he just posted both his lowest passer rating and completion percentage as he’s yet to throw a touchdown in two road starts. The model also says the Over hits nearly 60% of the time. See which other teams to pick here.
How to make Week 5 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 5 NFL schedule and just revealed four coveted A-rated spread picks, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what Week 5 NFL picks can you make with confidence, and which four teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
