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24x7Report > Blog > Sports > Cardinals vs. Seahawks prediction, odds, time: 2025 NFL Week 4 Thursday Night Football picks from proven model
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Cardinals vs. Seahawks prediction, odds, time: 2025 NFL Week 4 Thursday Night Football picks from proven model

Last updated: 2025/09/25 at 1:22 AM
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Why the Seahawks can cowlWhy the Cardinals can cowlThe best way to make Cardinals vs. Seahawks picks

An NFC West conflict kicks off NFL Week 4 on ‘Thursday Night time Soccer’ because the Seattle Seahawks go to the Arizona Cardinals. Each groups are 2-1, with the Seahawks coming off back-to-back victories. Seattle rolled over the Saints 44-13 in Week 3 after one other double-digit victory over Pittsburgh in Week 2. In the meantime, Arizona suffered its first lack of the yr in a 16-15 defeat to the 49ers on Sunday. This rivalry hasn’t been a lot of that in latest conferences because the Seahawks have taken every of the final seven matchups.

Kickoff is at 8:15 p.m. ET from State Farm Stadium in Glendale, Ariz. The newest Seahawks vs. Cardinals odds have Seattle because the 1.5-point favourite, whereas the over/below for complete factors is 43.5. Earlier than making any Cardinals vs. Seahawks picks, remember to see what the SportsLine projection model has to say. 

New customers may also goal the DraftKings promo code, which presents $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The mannequin, which simulates each NFL sport 10,000 instances, is up properly over $7,000 for $100 gamers on top-rated NFL picks since its inception. The mannequin is on a scorching 39-19 run on top-rated picks relationship again to 2024. Anyone following its NFL betting picks at sportsbooks and on betting websites might have seen sturdy returns.

Now, the mannequin has zeroed in on Seattle vs. Arizona. You can head to SportsLine now to see its picks. Listed below are a number of NFL odds and betting traces for Cardinals vs. Seahawks:

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Seahawks vs. Cardinals unfold

Seattle -1.5 at DraftKings Sportsbook

Seahawks vs. Cardinals over/below

43.5 factors

Seahawks vs. Cardinals cash line 

Arizona +103, Seattle -123

Seahawks vs. Cardinals picks

See picks at SportsLine

Seahawks vs. Cardinals streaming 

Amazon Prime

Why the Seahawks can cowl

Seattle’s using a seven-game win streak versus Arizona, with 5 of these victories coming by double-digits. None of these wins got here with Sam Darnold below heart, however the well-traveled quarterback has been among the many greatest versus the unfold in latest seasons. Darnold is 17-9-1 ATS because the begin of 2022, with that 65% cowl price the second-best amongst quarterbacks over this span. Darnold’s over/below for passing yardage is 223.5. 

Since Mike Macdonald turned Seattle’s head coach in 2024, Seattle is 5-1 ATS as a highway underdog. This yr’s squad is excelling on either side of the ball, rating within the prime 5 in each scoring offense and scoring protection. Seattle is the one NFL staff that hasn’t allowed a dashing landing this yr, making it an much more arduous job for Arizona to search out success on the bottom because the staff misplaced 1,000-yard rusher James Conner (leg) for the season on Sunday. See which team to back at SportsLine. 

Why the Cardinals can cowl

Regardless of coming off a loss to San Francisco, Arizona did handle to cowl within the sport and is now 10-4 ATS over its final 14 video games. Head coach Jonathan Gannon continues to work wonders on the defensive aspect of the ball because the Playing cards ranked thirty first in scoring protection in 2023, then fifteenth in 2024 and at the moment are fifth this season. The Cardinals make an opponent one-dimensional on offense after which carry out their greatest in clutch conditions as Arizona ranks top-five in dashing protection, third-down protection and redzone protection.

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Whereas Conner’s damage is an emotional setback for Arizona, it does permit the staff to make the most of second-year again, Trey Benson, extra. His 6.0 yards per carry rank second within the NFL, whereas Kyler Murray’s 5.4 yards per rush are seventh-best. Moreover, simply 4 groups have a greater turnover differential than the Playing cards, which the mannequin has taken into consideration. SportsLine’s projections forecast Arizona’s protection to each rack up extra sacks than Seattle’s and to power extra turnovers on Thursday. See which team to back at SportsLine. 

New customers may also try the most recent FanDuel promo code to get $300 in bonus bets after placing a $5 wager:

The best way to make Cardinals vs. Seahawks picks

For the NFL Week 4 Thursday Night time Soccer sport of Seahawks vs. Cardinals, the mannequin is leaning Over the whole, and in addition says one aspect of the unfold hits greater than 50% of the time. See what it is at SportsLine.

Who wins Cardinals vs. Seahawks, and which aspect of the unfold hits greater than 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. Cardinals spread you need to jump, all from the model that is 39-19 on top-rated picks since 2024, and discover out.

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