Bears vs. 49ers prediction, odds, time: ‘Sunday Night Football’ picks by proven model

A potential playoff preview takes place on ‘Sunday Night Football’ in NFL Week 17 as the Chicago Bears visit the San Francisco 49ers. Both teams are 11-4 and have already clinched postseason spots, but each still has a shot at the NFC’s top overall seed if they win out. Chicago is coming off a 22-16 victory on Saturday over Green Bay, while San Francisco enters in off a 48-27 win over Indianapolis on Monday. George Kittle (ankle) and Ricky Pearsall (knee) are listed as questionable, while Rome Odunze (foot) is out.

Kickoff is at 8:20 p.m. ET from Levi’s Stadium in Santa Clara, Calif. These teams have alternated wins and losses over their last eight meetings, with San Fran prevailing in the last matchup. The latest 49ers vs. Bears odds have San Francisco as 3.5-point favorites, while the over/under for total points scored is 51.5 via DraftKings Sportsbook. Before making any Bears vs. 49ers picks, check out the NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on 49ers vs. Bears. You can visit SportsLine now to see the picks. Here are the NFL odds and betting trends for Bears vs. Niners:

Why the Bears can cover

Chicago is undefeated ATS over its last six games and also has a two-day rest advantage from having played last Saturday, while San Fran is coming off a ‘MNF’ appearance. The Niners are just 6-8 ATS over their last 14 games when at a rest disadvantage. On the field, the Bears lead the NFL in the statistic that most correlates with winning and losing, and that’s turnover differential. Chicago is plus-21 in that regard, while the second-place team is at just plus-15. Chicago has forced the most turnovers (31) and it has committed the second-fewest (10). When the Niners lose the turnover battle this season, they are just 3-4 against the spread, and San Francisco’s defense has the fewest sacks in the NFL. See which team to back at SportsLine. 

Why the 49ers can cover

Riding a five-game win streak, San Francisco leads the NFL in points per game, points per drive and 3rd-down offense during this run, and each of the five victories have come by double-digits. The offense has been unstoppable over the last two games in particular, as the Niners are just the fifth team in the last 75 years to go back-to-back outings without punting the ball. Though he doesn’t qualify for statistical leaderboards due to time missed, Brock Purdy leads the NFL in QBR and is among the top five in touchdown percentage, completion percentage and passer rating. Additionally, the 49ers are 4-0 both straight up and ATS on primetime in 2025. See which team to back at SportsLine.

How to make Bears vs. 49ers picks

SportsLine’s model has simulated Niners vs. Bears 10,000 times is going Over on the total, projecting 53 combined points. It also says one side of the spread hits over 50% of the time. You can only get the pick at SportsLine. 

So who wins Bears vs. Niners, and which side of the spread hits in over 50% of simulations? Visit SportsLine now to see which side of the 49ers vs. Bears spread to jump on, all from the advanced model that finished up over $7,000 on its NFL picks since its inception, and find out.